AGR2 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A12411-20, A12411-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression.
Synonyms: AG2; AG-2; HPC8; GOB-4; HAG-2; RIFTD; XAG-2; PDIA17; HEL-S-116; AGR2
GeneID: 10551
Swiss Prot: O95994
Tested Applications: ELISA, WB, IF/ICC
Reactivity: Human, Mouse
Calculated Molecular Weight: 20kDa
Observed Molecular Weight: 18kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human AGR2 (O95994).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000 | IF/ICC: 1:50 - 1:200
Research Areas: Cancer, Tumor biomarkers, Cell Biology Developmental Biology, Stem Cells
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HT-29
Cellular Location: Endoplasmic Reticulum, Secreted,
Keywords: AGR2, AG-2, AG2, GOB-4, HAG-2, HEL-S-116, HPC8, PDIA17, XAG-2, anterior gradient 2, protein disulphide isomerase family member, anterior gradient protein 2 homolog|anterior gradient homolog 2|epididymis secretory protein Li 116|protein disulfide isomerase family A, member 17|secreted cement gland homolog|secreted cement gland protein XAG-2 homolog, O95994, marker, Mitochondria, Mitochondria marker
Symbol: AGR2
Category: Monoclonal Antibodies
Research Use Only