DNA Polymerase gamma Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A1323-20, A1323-100
Citations, Manuals and SDS Available upon request.
Background: Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.
Synonyms: PEO; MDP1; SCAE; MIRAS; POLG1; POLGA; SANDO; MTDPS4A; MTDPS4B; DNA Polymerase gamma
GeneID: 5428
Swiss Prot: P54098
Tested Applications: ELISA, WB
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 140kDa
Observed Molecular Weight: 140kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1140-1239 of human DNA Polymerase gamma (P54098).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000
Research Areas: Epigenetics Nuclear Signaling, Endocrine Metabolism, Mitochondrial metabolism, Nucleotide metabolism
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HT-29, 293T, Mouse testis, Mouse brain, Rat liver, Rat testis
Cellular Location: Mitochondrion, Mitochondrion Matrix, Mitochondrion nucleoid,
Keywords: POLG, MDP1, MIRAS, MTDPS4A, MTDPS4B, PEO, POLG1, POLGA, SANDO, SCAE, DNA polymerase gamma, catalytic subunit, DNA polymerase subunit gamma-1|PolG-alpha|mitochondrial DNA polymerase catalytic subunit|polymerase (DNA directed), gamma|polymerase (DNA) gamma, catalytic subunit|truncated mitochondrial DNA polymerase gamma catalytic subunit, P54098, DNA Polymerase gamma
Symbol: POLG
Category: Monoclonal Antibodies
Research Use Only