ESRα Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A12976-20, A12976-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes an estrogen receptor and ligand-activated transcription factor. The canonical protein contains an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain. The protein localizes to the nucleus where it may form either a homodimer or a heterodimer with estrogen receptor 2. The protein encoded by this gene regulates the transcription of many estrogen-inducible genes that play a role in growth, metabolism, sexual development, gestation, and other reproductive functions and is expressed in many non-reproductive tissues. The receptor encoded by this gene plays a key role in breast cancer, endometrial cancer, and osteoporosis. This gene is reported to have dozens of transcript variants due to the use of alternate promoters and alternative splicing, however, the full-length nature of many of these variants remain uncertain.
Synonyms: ER; ESR; Era; ESRA; ESTRR; NR3A1; ESRα
GeneID: 2099
Swiss Prot: P03372
Tested Applications: ELISA, WB
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 66kDa
Observed Molecular Weight: 66kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Estrogen Receptor alpha (ESRα) (P03372).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:1000 - 1:2000
Research Areas: Epigenetics Nuclear Signaling, Transcription Factors, Nuclear Receptor Signaling, Protein phosphorylation, Signal Transduction, MAPK-Erk Signaling Pathway
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: MCF7
Cellular Location: Cell Membrane, Cytoplasm, Cytoplasmic Side, Cytoplasmic Side, Golgi Apparatus, Nucleus, Peripheral Membrane Protein, Single-pass Type I Membrane Protein,
Keywords: 2099, sc-542, sc-543, sc-544, sc-7207, ER, ER alpha, Era, ESR, ESR1, ESRA, Estradiol receptor, Estrogen receptor, estrogen receptor 1, NR3A1, ESTRR, estrogen receptor, ER-alpha, estradiol receptor, estrogen nuclear receptor alpha, estrogen receptor alpha E1-E2-1-2, estrogen receptor alpha E1-N2-E2-1-2, nuclear receptor subfamily 3 group A member 1, P03372, Estrogen Receptor 1, Nuclear Receptor Subfamily 3 Group A Member 1, Oestrogen Receptor Alpha, Estradiol Receptor, E2 Receptor Alpha, ER-Alpha, Estrogen Receptor Alpha E1-N2-E2-1-2, Estrogen Receptor Alpha E1-E2-1-2, Estrogen Nuclear Receptor Alpha, Estrogen Receptor Alpha, Estrogen Receptor, Estrogen Receptor alpha, DKFZp686N23123, ESRα
Symbol: ESR1
Category: Monoclonal Antibodies
Research Use Only