HSPB8/HSP22 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A13518-20, A13518-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.
Synonyms: H11; HMN2; CMT2L; DHMN2; E2IG1; HMN2A; HSP22; CRYAC; HSPB8/HSP22
GeneID: 26353
Swiss Prot: Q9UJY1
Tested Applications: ELISA, WB, IF/ICC
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 22kDa
Observed Molecular Weight: 24kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HSPB8/HSP22 (Q9UJY1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000 | IF/ICC: 1:50 - 1:200
Research Areas: Signal Transduction, Neuroscience, Neurodegenerative Diseases
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Mouse heart, Rat heart
Cellular Location: Cytoplasm, Nucleus
Keywords: HSPB8, CMT2L, DHMN2, E2IG1, H11, HMN2, HMN2A, HSP22, heat shock protein family B (small) member 8, heat shock protein beta-8|E2-induced gene 1 protein|alpha-crystallin C chain|heat shock 22kDa protein 8|heat shock 27kDa protein 8|protein kinase H11|small stress protein-like protein HSP22, Q9UJY1, HSPB8/HSP22
Symbol: HSPB8
Category: Monoclonal Antibodies
Research Use Only