IDO1 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A12125-20, A12125-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes indoleamine 2, 3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.
Synonyms: IDO; INDO; IDO-1; IDO1
GeneID: 3620
Swiss Prot: P14902
Tested Applications: ELISA, IHC-P
Reactivity: Human, Mouse
Calculated Molecular Weight: 45kDa
Observed Molecular Weight: 42kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human IDO1 (P14902).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: IHC-P: 1:50 - 1:200
Research Areas: Cancer, Signal Transduction, Endocrine Metabolism, Amino acid metabolism, Immunology Inflammation, Cardiovascular
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Mouse ovary
Cellular Location: Cytoplasm, Cytosol
Keywords: IDO1, IDO, IDO-1, INDO, indoleamine 2, 3-dioxygenase 1, 3-dioxygenase 1|indolamine 2, 3 dioxygenase|indole 2, 3-dioxygenase|indoleamine-pyrrole 2, 3-dioxygenase, P14902
Symbol: IDO1
Category: Monoclonal Antibodies
Research Use Only