IL10 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A12255-20, A12255-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
Synonyms: CSIF; TGIF; GVHDS; IL-10; IL10A; IL10
GeneID: 3586
Swiss Prot: P22301
Tested Applications: ELISA, WB, IF/ICC
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 21kDa
Observed Molecular Weight: 18kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human IL10 (P22301).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000 | IF/ICC: 1:50 - 1:200
Research Areas: Cancer, Tumor immunology, Cell Biology Developmental Biology, Apoptosis, Growth factors, Immunology Inflammation, Cytokines, Interleukins, Cell Intrinsic Innate Immunity Signaling Pathway
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: THP-1, Mouse spleen, Rat thymus, HeLa
Cellular Location: Extra Cellular Region, Extra Cellular Space
Keywords: IL10, CSIF, GVHDS, IL-10, IL10A, TGIF, interleukin 10, interleukin-10|T-cell growth inhibitory factor|cytokine synthesis inhibitory factor, P22301
Symbol: IL10
Category: Monoclonal Antibodies
Research Use Only