KLF4 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A13673-20, A13673-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms: EZF; GKLF; KLF4
GeneID: 9314
Swiss Prot: O43474
Tested Applications: ELISA, WB, IHC-P, IF/ICC, IP
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 55kDa
Observed Molecular Weight: 55kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 300-400 of human KLF4 (O43474).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000 | IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200 | IP: 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Research Areas: Epigenetics Nuclear Signaling, Transcription Factors, Cancer, Tumor suppressors, Cell Biology Developmental Biology, Cell Cycle, Cell cycle inhibitors, Cell differentiation, Stem Cells, Embryonic Stem Cells, Cardiovascular, Heart, Hypertrophy
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: A549, A-431, HeLa, Mouse lung
Cellular Location: Nucleus
Keywords: KLF4, EZF, GKLF, Kruppel like factor 4, Krueppel-like factor 4|Kruppel-like factor 4 (gut)|endothelial Kruppel-like zinc finger protein|epithelial zinc finger protein EZF|gut Kruppel-like factor|gut-enriched krueppel-like factor, O43474
Symbol: KLF4
Category: Monoclonal Antibodies
Research Use Only