[KO Validated] MEK7 Rabbit mAb - A12950

[KO Validated] MEK7 Rabbit mAb

Sizes: 20µl, 100µl

Catalogue Numbers: A12950-20, A12950-100

Citations, Manuals and SDS Available upon request.

Background: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants.

Synonyms: MEK; MKK7; JNKK2; MEK 7; MAPKK7; PRKMK7; SAPKK4; SAPKK-4; K7

GeneID: 5609

Swiss Prot: O14733

Tested Applications: ELISA, WB

Reactivity: Human, Mouse, Rat

Calculated Molecular Weight: 47kDa

Observed Molecular Weight: 48kDa

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 320-419 of human MEK7 (O14733).

Immunogen Species: Human

Host: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.

Recommended Dilutions: WB: 1:500 - 1:2000

Research Areas: Protein phosphorylation, Signal Transduction, G protein signaling, G-Protein-Coupled Receptors Signaling to MAPK Erk, Kinase, ErbB-HER Signaling Pathway, MAPK-JNK Signaling Pathway, Cell Biology Developmental Biology, Cytoskeleton, Actins, Death Receptor Signaling Pathway, Endocrine Metabolism, Immunology Inflammation, B Cell Receptor Signaling Pathway, T Cell Receptor Signaling Pathway, Jak-Stat-IL-6 Receptor Signaling Pathway, Toll-like Receptor Signaling Pathway, Cell Intrinsic Innate Immunity Signaling Pathway, TLR Signaling, Neuroscience, Neurodegenerative Diseases, Dopamine Signaling in Parkinson's Disease

Modifications: Unmodified

Conjugate: Unconjugated

Positive Samples: 293T

Cellular Location: Cytoplasm, Nucleus

Keywords: MAP2K7, JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK-4, SAPKK4, mitogen-activated protein kinase kinase 7, dual specificity mitogen-activated protein kinase kinase 7|JNK-activating kinase 2|MAP kinase kinase 7|MAPK/ERK kinase 7|SAPK kinase 4|c-Jun N-terminal kinase kinase 2|stress-activated protein kinase kinase 4, O14733, K7

Symbol: MAP2K7

Category: Monoclonal Antibodies

Research Use Only