Ku80 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A12338-20, A12338-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
Synonyms: KU80; KUB2; Ku86; NFIV; KARP1; KARP-1; Ku80
GeneID: 7520
Swiss Prot: P13010
Tested Applications: ELISA, WB, IHC-P, IF/ICC, IP
Reactivity: Human, Mouse
Calculated Molecular Weight: 83kDa
Observed Molecular Weight: 86kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 633-732 of human Ku80 (P13010).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000 | IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200 | IP: 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Research Areas: Epigenetics Nuclear Signaling, DNA Damage Repair, RNA Binding
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HeLa, A-549, MCF7
Cellular Location: Chromosome, Nucleus, Nucleolus
Keywords: XRCC5, KARP-1, KARP1, KU80, KUB2, Ku86, NFIV, X-ray repair cross complementing 5, X-ray repair cross-complementing protein 5|86 kDa subunit of Ku antigen|ATP-dependent DNA helicase 2 subunit 2|ATP-dependent DNA helicase II 80 kDa subunit|CTC box-binding factor 85 kDa subunit|CTC85|CTCBF|DNA repair protein XRCC5|Ku autoantigen, 80kDa|Ku86 autoantigen related protein 1|TLAA|X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)|lupus Ku autoantigen protein p86|nuclear factor IV|thyroid-lupus autoantigen, P13010, Ku80
Symbol: XRCC5
Category: Monoclonal Antibodies
Research Use Only