PCNA Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A12427-20, A12427-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.
Synonyms: ATLD2; PCNA
GeneID: 5111
Swiss Prot: P12004
Tested Applications: ELISA, WB, IHC-P
Reactivity: Human, Mouse, Rat, African green monkey
Calculated Molecular Weight: 29kDa
Observed Molecular Weight: 35kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 162-261 of human PCNA (NP_002583.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000 | IHC-P: 1:2000 - 1:10000
Research Areas: Epigenetics Nuclear Signaling, Cancer, Tumor biomarkers, Signal Transduction, ErbB-HER Signaling Pathway, Cell Biology Developmental Biology, Cell Cycle, Stem Cells
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HeLa, MCF7, 293T, C2C12, COS-7, Mouse spleen, Rat testis
Cellular Location: Nucleus
Keywords: PCNA, ATLD2, proliferating cell nuclear antigen, proliferating cell nuclear antigen|DNA polymerase delta auxiliary protein|cyclin, P12004, 病理诊断抗体, IHC pathology, 病理诊断, 病理診斷抗體, 病理診斷
Symbol: PCNA
Category: Monoclonal Antibodies
Research Use Only