CAPN6 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A13777-20, A13777-100
Citations, Manuals and SDS Available upon request.
Background: Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis.
Synonyms: CANPX; CAPNX; CalpM; DJ914P14.1; CAPN6
GeneID: 827
Swiss Prot: Q9Y6Q1
Tested Applications: ELISA, WB
Reactivity: Rat
Calculated Molecular Weight: 75kDa
Observed Molecular Weight: 68kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human CAPN6 (NP_055104.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Ubiquitin, Neuroscience, Calcium Signaling
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Rat heart
Cellular Location: Cytoplasm, Cytoskeleton, Perinuclear Region, Spindle,
Keywords: 827, sc-54710, sc-54657, sc-54711, CAPN6, CANPX, CAPNX, CalpM, DJ914P14.1, calpain 6, calpain-6, calpain-like protease X-linked, calpamodulin, Q9Y6Q1, Calpain 6, Calpain-Like Protease X-Linked, Calpamodulin, Calpain-6, CALPM, Calpain like protease X linked
Symbol: CAPN6
Category: Polyclonal Antibodies
Research Use Only