KLHL3 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A13771-20, A13771-100
Citations, Manuals and SDS Available upon request.
Background: This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D); a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms: PHA2D; KLHL3
GeneID: 26249
Swiss Prot: Q9UH77
Tested Applications: ELISA, WB
Reactivity: Human, Mouse
Calculated Molecular Weight: 65kDa
Observed Molecular Weight: 75kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human KLHL3 (NP_059111.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000
Research Areas: Cell Biology Developmental Biology
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: 293T, A-549, Mouse liver
Cellular Location: Cytoplasm, Cytoskeleton, Cytosol,
Keywords: 26249, sc-133714, KLHL3, PHA2D, kelch like family member 3, kelch-like protein 3, Q9UH77, Kelch Like Family Member 3, Kelch (Drosophila)-Like 3, Kelch-Like 3 (Drosophila), Kelch-Like Protein 3, KIAA1129, FLJ40871, kelch like 3 (Drosophila), Kelch like protein 3
Symbol: KLHL3
Category: Polyclonal Antibodies
Research Use Only