MAN2B1 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A9937-20, A9937-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms: MANB; LAMAN; MAN2B1
GeneID: 4125
Swiss-Prot: O00754
Reactivity: Mouse
Calculated Molecular Weight: 114kDa
Observed Molecular Weight: 170kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 640-850 of human MAN2B1 (NP_000519.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000
Research Areas: Cancer, Signal Transduction, Endocrine Metabolism, Neuroscience
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Mouse liver
Cellular Location: Lysosome,
Category: Polyclonal Antibodies
Citations, Manuals and SDS Available upon request.