PSMB3 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A9947-20, A9947-100
Citations, Manuals and SDS Available upon request.
Background: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. The 26 S proteasome may be involved in trinucleotide repeat expansion, a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12. Alternative splicing results in multiple transcript variants
Synonyms: HC10-II; PSMB3
GeneID: 5691
Swiss-Prot: P49720
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 23kDa
Observed Molecular Weight: 23kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-205 of human PSMB3 (NP_002786.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IHC-P
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000 | IHC-P: 1:50 - 1:200
Research Areas: Cell Biology Developmental Biology, Ubiquitin
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: NIH/3T3, MCF7, HeLa, Jurkat, Mouse brain, Rat liver, Rat brain
Cellular Location: Cytoplasm, Nucleus
Category: Polyclonal Antibodies
Citations, Manuals and SDS Available upon request.