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Collection: Stem Cell Culture Coating


Cells are dependent on their niche

The extracellular matrix (ECM) is a complex network of proteins and polysaccharide chains that is secreted by cells. The image left shows a simplified view of the in vivo ECM that is a key contributor to the cellular microenvironment, also called the cell niche. The ECM is not just an inert structure. It is a dynamic network in which its components are in direct exchange with resident cells. Thus, the ECM serves specific roles, which contribute to cellular function as well as mechanical properties of tissues.

 
 

denovoMATRIX recapitulates key functions of the niche

In vitro, culture conditions are usually extremely simplified with respect to representing the natural function of the ECM. Generally, in vitro cell culture serves a minimalist approach that utilizes single ECM proteins or RGD-containing peptides to stimulate integrin binding and therefore cell adhesion.

denovoMATRIX biomaterials combine specific peptides and polysaccharide chains of the glycosaminoglycan type to recapitulate the key functions of the cell niche in vitro. While the peptides facilitate integrin binding and signaling, the glycosaminoglycans act as growth factor reservoirs and thus support cell adhesion and signaling.

Each cell, whether it is a stem cell or a somatic cell, has different requirements and therefore their own specific niche. 



3 products
  • myMATRIX iPSC (5 Pack) - Stem Cell Culture Coating
    myMATRIX iPSC (5 Pack) - Stem Cell Culture Coating
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    $73.08 CAD
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  • myMATRIX MSC (5 Pack) - Stem Cell Culture Coating
    myMATRIX MSC (5 Pack) - Stem Cell Culture Coating
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    $129.92 CAD
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  • screenMATRIX 5-pack - Stem Cell Culture Coating
    screenMATRIX 5-pack - Stem Cell Culture Coating
    Regular price
    $720.60 CAD
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