{"product_id":"β-arrestin-1-phospho-ser412-rabbit-polyclonal-antibody-ra36694","title":"β-Arrestin 1 (phospho-Ser412) Rabbit Polyclonal Antibody - RA36694","description":"\u003cp\u003eβ-Arrestin 1 (phospho-Ser412) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA36694-50, RA36694-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: arrestin beta 1 (ARRB1) Homo sapiens Members of arrestin\/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK\/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011],\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: WB 1:1000-2000\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: Beta-arrestin-1 (Arrestin beta-1)\u003c\/p\u003e \n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 408\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 47\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P49407\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45122493972659,"sku":"RA36694-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45122494005427,"sku":"RA36694-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_3e70b725-916f-49a0-b84c-ef0c6b9fe2d6.png?v=1773343243","url":"https:\/\/afsbio.com\/products\/%ce%b2-arrestin-1-phospho-ser412-rabbit-polyclonal-antibody-ra36694","provider":"AFSBio Inc.","version":"1.0","type":"link"}