{"product_id":"β-iii-tubulin-rabbit-polyclonal-antibody-es20590","title":"β III Tubulin Rabbit Polyclonal Antibody - ES20590","description":"\u003cp\u003eβ III Tubulin Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES20590-50, ES20590-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: tubulin beta 3 class III(TUBB3) Homo sapiens This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: TUBB3, TUBB4, Tubulin beta-3 chain, Tubulin beta-4 chain, Tubulin beta-III\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic Peptide of β III Tubulin AA range: 134-184\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: Tubulin β\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: The antibody detects endogenous β III tubulin protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB: 1:2000-5000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormlation: PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Expression is primarily restricted to central and peripheral nervous system, Greatly increased expression in most cancerous tissues,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 50kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Phagosome, Gap junction, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection\u003c\/p\u003e\n\n\u003cp\u003eFunction: Domain: The highly acidic C-terminal region may bind cations such as calcium\u003cbr\u003e\nFunction: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase\u003cbr\u003e\nFunction: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain\u003cbr\u003e\npolymorphism: Genetic variations in MC1R are associated with variation in skin\/hair\/eye pigmentation type 2 (SHEP2) [MIM: 266300]. Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification. In the case of skin, individuals tend to have lighter pigmentation with increasing distance from the equator. By contrast, the majority of variation in human eye and hair col\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasm, cytoskeleton Cell projection, growth cone Cell projection, lamellipodium Cell projection, filopodium\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: TUBB3\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Tubulin beta-3 chain\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 22152\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q9ERD7\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 246118\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q4QRB4\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314184933555,"sku":"ES20590-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314184966323,"sku":"ES20590-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/%ce%b2-iii-tubulin-rabbit-polyclonal-antibody-es20590","provider":"AFSBio Inc.","version":"1.0","type":"link"}