{"product_id":"μlk1-polyclonal-antibody-bs91404","title":"μlK1 Polyclonal Antibody - BS91404","description":"\u003cp\u003eμlK1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS91404-50, BS91404-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Serine\/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regμlate the formation of autophagophores, the precursors of autophagosomes. Part of regμlatory feedback loops in autophagy: acts both as a downstream effector and negative regμlator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regμlator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regμlate AMPK activity. May phosphorylate ATG13\/KIAA0652 and RPTOR, however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granμle cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regμlate autophagy.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Serine\/threonine-protein kinaseμlK1, Autophagy-related protein 1 homolog (ATG1, Hatg1, Unc-51-like kinase 1,μlK1, KIAA0722\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to HumanμlK1.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB:1:500-1:1, 000\u003cbr\u003e\nIHC:1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: μlK1 polyclonal antibody detects endogenous levels ofμlK1 protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 150 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: PI3K AKT signaling, MTOR signaling,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: O75385\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946386940083,"sku":"BS91404-50","price":424.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946386972851,"sku":"BS91404-100","price":642.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/%ce%bclk1-polyclonal-antibody-bs91404","provider":"AFSBio Inc.","version":"1.0","type":"link"}