{"product_id":"14-3-3-sigma-phospho-ser186-rabbit-polyclonal-antibody-bt-ap00496","title":"14-3-3 sigma (Phospho Ser186) Rabbit Polyclonal Antibody - BT-AP00496","description":"\u003cp\u003e14-3-3 sigma (Phospho Ser186) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP00496-20, BT-AP00496-50, BT-AP00496-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners| usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17| regulates protein synthesis and epithelial cell growth by stimulating Akt\/mTOR pathway.|p53-regulated inhibitor of G2\/M progression.|Belongs to the 14-3-3 family.|subcellular location:May be secreted by a non-classical secretory pathway.|subunit:Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7| EIF4A1| ARHGAP1| VPS26A| VPS29| VPS35 and SFN.|tissue specificity:Present mainly in tissues enriched in stratified squamous keratinising epithelium.|\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Neuroscience; Signal transduction; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: SFN\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Stratifin\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 27280\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P31947; Mouse: O70456\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Stratifin; 14-3-3 protein sigma; Epithelial cell marker protein 1; Stratifin\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 2810; Mouse: 55948\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240054415539,"sku":"BT-AP00496-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240054448307,"sku":"BT-AP00496-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240054481075,"sku":"BT-AP00496-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_1c13bef9-5bd7-456c-9fe5-90731500584a.png?v=1769402771","url":"https:\/\/afsbio.com\/products\/14-3-3-sigma-phospho-ser186-rabbit-polyclonal-antibody-bt-ap00496","provider":"AFSBio Inc.","version":"1.0","type":"link"}