{"product_id":"14-3-3-sigma-polyclonal-antibody-bt-ap00014","title":"14-3-3 Sigma Polyclonal Antibody - BT-AP00014","description":"\u003cp\u003e14-3-3 Sigma Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP00014-20, BT-AP00014-50, BT-AP00014-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: SFN (Stratifin) is a Protein Coding gene. Diseases associated with SFN include pancreatic ductal adenocarcinoma and limbal stem cell deficiency. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include protein kinase binding and phosphoprotein binding. An important paralog of this gene is YWHAZ. dapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt\/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53\/TP53. 53-regulated inhibitor of G2\/M progression.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Neuroscience; Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: SFN\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: 14-3-3 sigma Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 27774\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P31947; Mouse: O70456\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: SFN; HME1; 14-3-3 protein sigma; Epithelial cell marker protein 1; Stratifin\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 2810; Mouse: 55948\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240080007347,"sku":"BT-AP00014-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240080040115,"sku":"BT-AP00014-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240080072883,"sku":"BT-AP00014-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_a26fd4bc-b369-4b9a-9f28-0ee31f337373.png?v=1769403137","url":"https:\/\/afsbio.com\/products\/14-3-3-sigma-polyclonal-antibody-bt-ap00014","provider":"AFSBio Inc.","version":"1.0","type":"link"}