{"product_id":"53bp1-phospho-ser1778-rabbit-pab-es18530","title":"53BP1 (phospho-Ser1778) rabbit pAb - ES18530","description":"\u003cp\u003e53BP1 (phospho-Ser1778) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES18530-50, ES18530-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Name: Tumor suppressor p53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:1000-2000\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Rat; Mouse;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Synthesized phosho peptide around human 53BP1 (Ser1778)\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 213kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 7158\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q12888\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus. Chromosome. Chromosome, centromere, kinetochore. Localizes to the nucleus in absence of DNA damage (PubMed:28241136). Following DNA damage, recruited to sites of DNA damage, such as double stand breaks (DSBs): recognizes and binds histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23333306, PubMed:23760478, PubMed:24703952, PubMed:28241136, PubMed:17190600). Associated with kinetochores during mitosis (By similarity).\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45201578033331,"sku":"ES18530-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45201578066099,"sku":"ES18530-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_bc407327-4c57-4fbc-a37e-037a1e820ba5.png?v=1767106818","url":"https:\/\/afsbio.com\/products\/53bp1-phospho-ser1778-rabbit-pab-es18530","provider":"AFSBio Inc.","version":"1.0","type":"link"}