{"product_id":"a-actinin-monoclonal-antibody-4a12-bt-mca0115","title":"a-actinin Monoclonal Antibody (4A12) - BT-MCA0115","description":"\u003cp\u003ea-actinin Monoclonal Antibody (4A12)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-MCA0115-20, BT-MCA0115-50, BT-MCA0115-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction; Cancer; Metabolism\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ACTN1\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-p, IF\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human,Rat,Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: ACTN1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P12814; Mouse: Q7TPR4; Rat: Q9Z1P2\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: ACTN1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 87\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240030986419,"sku":"BT-MCA0115-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240031019187,"sku":"BT-MCA0115-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240031051955,"sku":"BT-MCA0115-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_2ca01a94-c6d4-4e5c-83a4-7c1313d28487.png?v=1769402405","url":"https:\/\/afsbio.com\/products\/a-actinin-monoclonal-antibody-4a12-bt-mca0115","provider":"AFSBio Inc.","version":"1.0","type":"link"}