{"product_id":"a-cyclase-viii-rabbit-pab-es4642","title":"A Cyclase VIII rabbit pAb - ES4642","description":"\u003cp\u003eA Cyclase VIII rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES4642-50, ES4642-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: ADCY8; Adenylate cyclase type 8; ATP pyrophosphate-lyase 8; Adenylate cyclase type VIII; Adenylyl cyclase 8; AC8; Ca (2+)\/calmodulin-activated adenylyl cyclase\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human ADCY8. AA range:591-640\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 114\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P40145\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Apical cell membrane. Cell junction, synapse. Cell projection, dendrite. Cell projection, axon. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic density. Membrane raft. Membrane, coated pit. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane, caveola. Localized to dendritic arbors (By similarity). Monomeric N-glycosylated species localizes in membrane raft. In contrast, monomeric unglycosylated forms are enriched in clathrin-coated pits and vesicles. Dimers are also localized outside of membrane rafts. Membrane raft localization and integrity is indispensable for CCE-stimulated adenylate cyclase activity (By similarity).\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45201806033075,"sku":"ES4642-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45201806065843,"sku":"ES4642-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_e8c2dc31-a7f9-4890-97a5-401b1f54f530.png?v=1767112241","url":"https:\/\/afsbio.com\/products\/a-cyclase-viii-rabbit-pab-es4642","provider":"AFSBio Inc.","version":"1.0","type":"link"}