{"product_id":"aak1-polyclonal-antibody-bt-ap00069","title":"AAK1 Polyclonal Antibody - BT-AP00069","description":"\u003cp\u003eAAK1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP00069-20, BT-AP00069-50, BT-AP00069-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. AAK1 encodes a member (AP2 associated kinase 1) of the SNF1 subfamily of Ser\/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: AAK1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat, Monkey\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: AAK1 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 93578\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q2M2I8; Mouse: Q3UHJ0; Rat: P0C1X8\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: AAK1; KIAA1048; AP2-associated protein kinase 1; Adaptor-associated kinase 1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 22848; Mouse: 269774\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240083087539,"sku":"BT-AP00069-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240083120307,"sku":"BT-AP00069-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240083153075,"sku":"BT-AP00069-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_40a6f226-ba57-44a4-bf5f-4599655b491d.png?v=1769403186","url":"https:\/\/afsbio.com\/products\/aak1-polyclonal-antibody-bt-ap00069","provider":"AFSBio Inc.","version":"1.0","type":"link"}