{"product_id":"abcbb-polyclonal-antibody-bt-ap14011","title":"ABCBB Polyclonal Antibody - BT-AP14011","description":"\u003cp\u003eABCBB Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP14011-20, BT-AP14011-50, BT-AP14011-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1| MDR\/TAP| MRP| ALD| OABP| GCN20| White). This protein is a member of the MDR\/TAP subfamily. Members of the MDR\/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cancer; Metabolism; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ABCB11\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Bile salt export pump\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: O95342; Mouse: Q9QY30; Rat: O70127\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Bile salt export pump;ATP-binding cassette sub-family B member 11\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 8647\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239036838067,"sku":"BT-AP14011-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239036870835,"sku":"BT-AP14011-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239036903603,"sku":"BT-AP14011-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_ef2dc22b-5c26-4c0b-af22-654ff4ebf3e9.png?v=1769388239","url":"https:\/\/afsbio.com\/products\/abcbb-polyclonal-antibody-bt-ap14011","provider":"AFSBio Inc.","version":"1.0","type":"link"}