{"product_id":"abflo®-488-rabbit-anti-human-cd158-kir2dl1-s1-s2-s3-s5-monoclonal-antibody-a26404","title":"ABflo® 488 Rabbit anti-Human CD158 (KIR2DL1\/S1\/S2\/S3\/S5) Monoclonal Antibody - A26404","description":"\u003cp\u003eABflo® 488 Rabbit anti-Human CD158 (KIR2DL1\/S1\/S2\/S3\/S5) Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 100T, 2 x 100T, 5 x 100T\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A26404-100, A26404-200, A26404-500\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several \"framework\" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.\u003c\/p\u003e \n\n\u003cp\u003eCategory: Monoclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplication: FC\u003c\/p\u003e\n\n\u003cp\u003eCross Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 34kDa Immunogen: Recombinant protein (or fragment).\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 3810\/3808\/3806\/3802\/100132285\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q14954\/Q14953\/Q14952\/P43631\/P43626\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: NKAT9; CD158G；CD158A；NKAT1; CD158H; CD158J; NKAT5\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at 2-8℃. Avoid freeze.|Buffer: PBS with 0.09% Sodium azide,0.2% BSA,pH7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction Cytoskeleton \/ ECM Cell Adhesion Integrins BetaImmunology Cell Type Markers CD AdhesionStem Cells Hematopoietic Progenitors Lymphoid T Lymphocytic LineageStem Cells Hematopoietic Progenitors Lymphoid NK Cell LineageStem Cells Hematopoietic Progenitors Myeloid Dendritic Cell LineageStem Cells Hematopoietic Progenitors Myeloid Monocytic LineageStem Cells Hematopoietic Progenitors Myeloid Mast Cell Lineage\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: KIR2DL1\/KIR2DS1\/KIR2DS2\/KIR2DS3\/KIR2DS5\u003c\/p\u003e\n\n\u003cp\u003eModifications: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: ABflo® 488. Ex:491nm. Em:516nm.\u003c\/p\u003e\n\n\u003cp\u003eClone Number Info: ARC67708\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"100T","offer_id":45189277974707,"sku":"A26404-100","price":263.2,"currency_code":"CAD","in_stock":true},{"title":"2 x 100T","offer_id":45189278007475,"sku":"A26404-200","price":445.2,"currency_code":"CAD","in_stock":true},{"title":"5 x 100T","offer_id":45189278040243,"sku":"A26404-500","price":809.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_e0375aa7-faf3-47b0-984b-69959cc64cca.png?v=1766420725","url":"https:\/\/afsbio.com\/products\/abflo%c2%ae-488-rabbit-anti-human-cd158-kir2dl1-s1-s2-s3-s5-monoclonal-antibody-a26404","provider":"AFSBio Inc.","version":"1.0","type":"link"}