{"product_id":"abflo®-488-rabbit-anti-human-cd46-monoclonal-antibody-a25550","title":"ABflo® 488 Rabbit anti-Human CD46 Monoclonal Antibody - A25550","description":"\u003cp\u003eABflo® 488 Rabbit anti-Human CD46 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 100T, 2 x 100T, 5 x 100T\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A25550-100, A25550-200, A25550-500\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Monoclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplication: FC\u003c\/p\u003e\n\n\u003cp\u003eCross Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 37-44kDa Immunogen: Recombinant protein (or fragment).\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 4179\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P15529\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: MCP; TLX; AHUS2; MIC10; TRA2.10\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at 2-8℃. Avoid freeze.|Buffer: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Immunology Inflammation, CDs, Cell Intrinsic Innate Immunity Signaling Pathway\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: CD46\u003c\/p\u003e\n\n\u003cp\u003eModifications: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: ABflo® 488. Ex:491nm. Em:516nm.\u003c\/p\u003e\n\n\u003cp\u003eClone Number Info: ARC65046\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"100T","offer_id":45189258412211,"sku":"A25550-100","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"2 x 100T","offer_id":45189258444979,"sku":"A25550-200","price":431.2,"currency_code":"CAD","in_stock":true},{"title":"5 x 100T","offer_id":45189258477747,"sku":"A25550-500","price":809.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_f8358e5a-07dc-400a-9c4c-54f24e7bbcb5.png?v=1766420402","url":"https:\/\/afsbio.com\/products\/abflo%c2%ae-488-rabbit-anti-human-cd46-monoclonal-antibody-a25550","provider":"AFSBio Inc.","version":"1.0","type":"link"}