{"product_id":"abflo®-488-rabbit-anti-human-monkey-cd25-monoclonal-antibody-a23169","title":"ABflo® 488 Rabbit anti-Human\/Monkey CD25 Monoclonal Antibody - A23169","description":"\u003cp\u003eABflo® 488 Rabbit anti-Human\/Monkey CD25 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 100T, 2 x 100T, 5 x 100T\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A23169-100, A23169-200, A23169-500\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Monoclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplication: FC\u003c\/p\u003e\n\n\u003cp\u003eCross Reactivity: Human, Cynomolgus\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 31kDa Immunogen: Recombinant protein (or fragment).\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 3559\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P01589\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: p55; CD25; IL2R; IMD41; TCGFR; IDDM10\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at 2-8℃. Avoid freeze.|Buffer: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology Developmental Biology, Apoptosis, Immunology Inflammation, CDs, Cytokines, Interleukins, Cell Intrinsic Innate Immunity Signaling Pathway\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: IL2RA\u003c\/p\u003e\n\n\u003cp\u003eModifications: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: ABflo® 488. Ex:491nm. Em:516nm.\u003c\/p\u003e\n\n\u003cp\u003eClone Number Info: ARC58045\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"100T","offer_id":45189184094387,"sku":"A23169-100","price":305.2,"currency_code":"CAD","in_stock":true},{"title":"2 x 100T","offer_id":45189184127155,"sku":"A23169-200","price":501.2,"currency_code":"CAD","in_stock":true},{"title":"5 x 100T","offer_id":45189184159923,"sku":"A23169-500","price":795.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_819c3b6c-8ffc-4cff-9d1e-f104024203de.png?v=1766419188","url":"https:\/\/afsbio.com\/products\/abflo%c2%ae-488-rabbit-anti-human-monkey-cd25-monoclonal-antibody-a23169","provider":"AFSBio Inc.","version":"1.0","type":"link"}