{"product_id":"abflo®-488-rabbit-anti-human-nectin-4-monoclonal-antibody-a25192","title":"ABflo® 488 Rabbit anti-Human Nectin-4 Monoclonal Antibody - A25192","description":"\u003cp\u003eABflo® 488 Rabbit anti-Human Nectin-4 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 100T, 2 x 100T, 5 x 100T\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A25192-100, A25192-200, A25192-500\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Nectin-4\/ poliovirus Receptor-like 4 (PVRL4) is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily that promotes intercellular adhesion by acting as a major component of adhesion junctions. The extracellular domain of Nectin-4 consists of one Ig variable region (V) and two Ig constant regions (C), which mediate binding to measles virus and adjacent cells through trans-heterophile interactions with Nectin-1. Unlike other members of the connectin family, which are widely expressed in adult tissues, human Nectin-4 expression is largely limited to the blastoderm. Studies have shown that Nectin-4 is overexpressed in cells from a variety of human solid tumors, including pancreatic, breast, lung, and ovarian cancers. The expression pattern of Nectin-4 in normal tissues is limited, so NECTIN-4 can be used as a novel therapeutic target for various human tumors.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Monoclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplication: FC\u003c\/p\u003e\n\n\u003cp\u003eCross Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 24kDa\/55kDa Immunogen: Recombinant protein (or fragment).\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 81607\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q96NY8\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: LNIR; PRR4; EDSS1; PVRL4; nectin-4\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at 2-8℃. Avoid freeze.|Buffer: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology Developmental Biology, Cell Adhesion, Tight Junctions\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: NECTIN4\u003c\/p\u003e\n\n\u003cp\u003eModifications: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: ABflo® 488. Ex:491nm. Em:516nm.\u003c\/p\u003e\n\n\u003cp\u003eClone Number Info: ARC66068\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"100T","offer_id":45189241733299,"sku":"A25192-100","price":406.0,"currency_code":"CAD","in_stock":true},{"title":"2 x 100T","offer_id":45189241766067,"sku":"A25192-200","price":672.0,"currency_code":"CAD","in_stock":true},{"title":"5 x 100T","offer_id":45189241798835,"sku":"A25192-500","price":1075.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_849acffc-c6db-4710-9a7b-68aacb873daa.png?v=1766420146","url":"https:\/\/afsbio.com\/products\/abflo%c2%ae-488-rabbit-anti-human-nectin-4-monoclonal-antibody-a25192","provider":"AFSBio Inc.","version":"1.0","type":"link"}