{"product_id":"abflo®-594-rabbit-anti-human-cd100-sema4d-monoclonal-antibody-a24407","title":"ABflo® 594 Rabbit anti-Human CD100\/SEMA4D Monoclonal Antibody - A24407","description":"\u003cp\u003eABflo® 594 Rabbit anti-Human CD100\/SEMA4D Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 100T, 2 x 100T, 5 x 100T\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A24407-100, A24407-200, A24407-500\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Plexin-B1 is related to axon guidance in the central nervous system. The Sema4D function is also widely detected in the immune system and was found to be the first semaphorin expressed on the surface of many types of immune cells. In the immune system, CD72 is a low-affinity receptor for Sema4D, and studies have shown that Sema4D can not only regulate T cell activation, but also participate in the regulation of B cell survival and differentiation. In the immune system, soluble fragments containing extracellular domains produced by proteolytic cleavage can regulate many physiological functions of Sema4D. Sema4D is also associated with tumorigenesis because studies have confirmed that it is overexpressed in various types of solid tumor cells. To some extent, the role of Sema4D in tumorigenesis is related to its ability to cause tumor angiogenesis, cell invasion, and immunosuppression by enhancing bone marrow-derived suppressor cell function.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Monoclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplication: IF\/ICC, FC\u003c\/p\u003e\n\n\u003cp\u003eCross Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 82kDa\/96kDa Immunogen: Recombinant protein (or fragment).\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 10507\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q92854\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: SEMA4D; C9orf164; CD100; M-sema-G; SEMAJ; coll-4; semaphorin-4D\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at 2-8℃. Avoid freeze.|Buffer: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilution: IF\/ICC,1:50 - 1:200|FC,5 μl per 10^6 cells in 100 μl volume\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology and Developmental Biology, Apoptosis, Immunology and Inflammation, CD markers, Neuroscience, Cell Type Marker\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: SEMA4D\u003c\/p\u003e\n\n\u003cp\u003eModifications: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: ABflo® 594. Ex:588nm. Em:604nm.\u003c\/p\u003e\n\n\u003cp\u003eClone Number Info: ARC63157\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"100T","offer_id":45189231018163,"sku":"A24407-100","price":305.2,"currency_code":"CAD","in_stock":true},{"title":"2 x 100T","offer_id":45189231050931,"sku":"A24407-200","price":501.2,"currency_code":"CAD","in_stock":true},{"title":"5 x 100T","offer_id":45189231083699,"sku":"A24407-500","price":795.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_686d9db3-6f42-4ae8-8ba1-cd6114246f13.png?v=1766419945","url":"https:\/\/afsbio.com\/products\/abflo%c2%ae-594-rabbit-anti-human-cd100-sema4d-monoclonal-antibody-a24407","provider":"AFSBio Inc.","version":"1.0","type":"link"}