{"product_id":"abflo®-594-rabbit-anti-human-icam-1-cd54-monoclonal-antibody-a24587","title":"ABflo® 594 Rabbit anti-Human ICAM-1\/CD54 Monoclonal Antibody - A24587","description":"\u003cp\u003eABflo® 594 Rabbit anti-Human ICAM-1\/CD54 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 100T, 2 x 100T, 5 x 100T\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A24587-100, A24587-200, A24587-500\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Intercellular cell adhesion molecule-1 (CD54 or ICAM-1) is a cell surface glycoprotein that belongs to the immunoglobulin superfamily (IgSF) of adhesion molecules. CD54 is expressed at low levels in diverse cell types, and is induced by cytokines (TNF-α, interleukin-1) and bacterial lipopolysaccharide . Apical localization of CD54 on endothelial cells (or basolateral localization on epithelial cells) is a prerequisite for leukocyte trafficking through the endothelial (or epithelial) barrier . Apical expression of CD54 on epithelial cells mediates pathogen invasion as well as host defense, a pattern also observed in tumors . CD54 also functions as a co-stimulator on antigen presenting cells, binding to its receptor LFA-1 (leukocyte function-associated antigen-1) on the surface of T cells during antigen presentation . Cross-linking of CD54 or binding to its ligand triggers activation of Src family kinases and the Rho\/ROCK pathway . Phosphorylation on Tyr485 of CD54 is required for its association with SHP-2. SHP-2 seems essential for CD54-induced Src activation.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Monoclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplication: FC\u003c\/p\u003e\n\n\u003cp\u003eCross Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 57kDa Immunogen: Recombinant protein (or fragment).\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 3383\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P05362\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ICAM1; BB2; CD54; P3.58; intercellular adhesion molecule 1\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at 2-8℃. Avoid freeze.|Buffer: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology and Developmental Biology, Cell Adhesion, Cell Adhesion Molecules, Immunology and Inflammation, CD markers, Neuroscience, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease, Neurodegenerative Diseases Markers, Stem Cells, Hematopoietic Progenitors, Cardiovascular\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: ICAM1\u003c\/p\u003e\n\n\u003cp\u003eModifications: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: ABflo® 594. Ex:588nm. Em:604nm.\u003c\/p\u003e\n\n\u003cp\u003eClone Number Info: ARC54998\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"100T","offer_id":45189223776435,"sku":"A24587-100","price":305.2,"currency_code":"CAD","in_stock":true},{"title":"2 x 100T","offer_id":45189223809203,"sku":"A24587-200","price":501.2,"currency_code":"CAD","in_stock":true},{"title":"5 x 100T","offer_id":45189223841971,"sku":"A24587-500","price":795.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_46b37f8c-ce4e-49c1-8059-0d6ed145580a.png?v=1766419836","url":"https:\/\/afsbio.com\/products\/abflo%c2%ae-594-rabbit-anti-human-icam-1-cd54-monoclonal-antibody-a24587","provider":"AFSBio Inc.","version":"1.0","type":"link"}