{"product_id":"abflo®-647-rabbit-anti-human-cd206-mmr-monoclonal-antibody-a28284","title":"ABflo® 647 Rabbit anti-Human CD206\/MMR Monoclonal Antibody - A28284","description":"\u003cp\u003eABflo® 647 Rabbit anti-Human CD206\/MMR Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 100T, 2 x 100T, 5 x 100T\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A28284-100, A28284-200, A28284-500\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The mannose receptor (MR\/CLEC13D\/CD206\/MMR\/MRC1\/Macrophage Mannose Receptor 1) is an endocytic receptor expressed on dendritic cells, macrophages, and avascular endothelium. It is a highly glycosylated type I transmembrane protein featuring three distinct types of extracellular domains and a short carboxyl-terminal cytoplasmic tail that lacks obvious signaling motifs. The extracellular portion of the protein comprises an N-terminal cysteine-rich (CR) domain that binds sulfated sugar chains, a single fibronectin type II (FNII) domain that binds collagen, and eight C-type lectin domains (CTLDs) that recognize carbohydrate ligands containing mannose, fucose, and N-acetylglucosamine (GlcNAc). The receptor continuously cycles between the plasma membrane and early endosomes. Its functions include mediating antigen cross-presentation, facilitating the clearance of endogenous glycoproteins (e.g., maintaining glycoprotein homeostasis), and detecting and transporting pathogens via the lymphatics. The mannose receptor is a canonical marker for M2 macrophages.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Monoclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplication: FC\u003c\/p\u003e\n\n\u003cp\u003eCross Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 166kDa Immunogen: Recombinant protein (or fragment).\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 4360\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P22897\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: MMR; hMR; CD206; MRC1L1; CLEC13D; CLEC13DL; bA541I19.1\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at 2-8℃. Avoid freeze.|Buffer: PBS with 0.09% Sodium azide,0.2% BSA,pH7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Immunology Inflammation, CDs\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: MRC1\u003c\/p\u003e\n\n\u003cp\u003eModifications: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: ABflo® 647. Ex:648nm. Em:664nm.\u003c\/p\u003e\n\n\u003cp\u003eClone Number Info: ARC70412\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"100T","offer_id":45189335974067,"sku":"A28284-100","price":333.2,"currency_code":"CAD","in_stock":true},{"title":"2 x 100T","offer_id":45189336006835,"sku":"A28284-200","price":585.2,"currency_code":"CAD","in_stock":true},{"title":"5 x 100T","offer_id":45189336039603,"sku":"A28284-500","price":1383.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_49523c08-4f35-4797-81d5-6553cbad1b9b.png?v=1766421659","url":"https:\/\/afsbio.com\/products\/abflo%c2%ae-647-rabbit-anti-human-cd206-mmr-monoclonal-antibody-a28284","provider":"AFSBio Inc.","version":"1.0","type":"link"}