{"product_id":"abflo®-647-rabbit-anti-human-ido1-monoclonal-antibody-a26649","title":"ABflo® 647 Rabbit anti-Human IDO1 Monoclonal Antibody - A26649","description":"\u003cp\u003eABflo® 647 Rabbit anti-Human IDO1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 100T, 2 x 100T, 5 x 100T\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A26649-100, A26649-200, A26649-500\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Monoclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplication: FC (intra)\u003c\/p\u003e\n\n\u003cp\u003eCross Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 45kDa Immunogen: Recombinant protein (or fragment).\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 3620\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P14902\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: IDO; INDO; IDO-1\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at 2-8℃. Avoid freeze.|Buffer: PBS with 0.09% Sodium azide,0.2% BSA,pH7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilution: FC (intra),5 μl per 10^6 cells in 100 μl volume\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Signal Transduction, Endocrine Metabolism, Amino acid metabolism, Immunology Inflammation, Cardiovascular\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: IDO1\u003c\/p\u003e\n\n\u003cp\u003eModifications: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: ABflo® 647. Ex:648nm. Em:664nm.\u003c\/p\u003e\n\n\u003cp\u003eClone Number Info: ARC67328\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"100T","offer_id":45189303599283,"sku":"A26649-100","price":669.2,"currency_code":"CAD","in_stock":true},{"title":"2 x 100T","offer_id":45189303632051,"sku":"A26649-200","price":1134.0,"currency_code":"CAD","in_stock":true},{"title":"5 x 100T","offer_id":45189303664819,"sku":"A26649-500","price":2097.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_4abf6a6d-9806-4abf-b963-f1c55a8e501d.png?v=1766421129","url":"https:\/\/afsbio.com\/products\/abflo%c2%ae-647-rabbit-anti-human-ido1-monoclonal-antibody-a26649","provider":"AFSBio Inc.","version":"1.0","type":"link"}