{"product_id":"abl1-monoclonal-antibody-bt-mca2718","title":"ABL1 Monoclonal Antibody - BT-MCA2718","description":"\u003cp\u003eABL1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2718-50, BT-MCA2718-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: ABL1: c-abl oncogene 1, receptor tyrosine kinase. The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction, Cancer\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ABL1\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 7B11D6\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: ABL1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of ABL1 (aa577-650) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P00519\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: ABL, JTK7, p150, c-ABL, v-abl\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 25\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238367682739,"sku":"BT-MCA2718-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238367715507,"sku":"BT-MCA2718-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_07f17e97-f57a-4f69-acb3-11883f3cddc9.png?v=1769379251","url":"https:\/\/afsbio.com\/products\/abl1-monoclonal-antibody-bt-mca2718","provider":"AFSBio Inc.","version":"1.0","type":"link"}