{"product_id":"abl1-polyclonal-antibody-bs65364","title":"Abl1 Polyclonal Antibody - BS65364","description":"\u003cp\u003eAbl1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS65364-50, BS65364-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: ABL proto-oncogene 1, non-receptor tyrosine kinase(ABL1) Homo sapiens This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellμlar processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regμlated by its SH3 domain, whereby deletion of the region encoding this domain resμlts in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regμlated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9, 22) translocation that resμlts in a fusion with the 5' end of the breakpoint cluster region gene (BCR, MIM:151410). Alternative splicing of this gene resμlts in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [pr\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat, Monkey\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, IF(paraffin, section), ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ABL1, ABL, JTK7, Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human Abl. AA range:156-205\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/5000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Abl1 Polyclonal Antibody detects endogenous levels of Abl1 protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~125 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: SAPK JNK Signaling Cascades,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P00519\u003c\/p\u003e\n\n\u003cp\u003eProduct: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946358005939,"sku":"BS65364-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946358038707,"sku":"BS65364-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/abl1-polyclonal-antibody-bs65364","provider":"AFSBio Inc.","version":"1.0","type":"link"}