{"product_id":"accn2-polyclonal-antibody-bs90019","title":"ACCN2 Polyclonal Antibody-BS90019","description":"\u003cp\u003eACCN2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS90019-50, BS90019-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P78348(Human) Q6NXK8(Mouse) P55926(Rat)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC FC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:500-1:2,000\u003cbr\u003e\nIHC:1:50-1:200\u003cbr\u003e\nFC:1:50-1:100\u003c\/p\u003e\n\n\u003cp\u003eBackground: Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.Isoform 1 does not display proton-gated cation channel activity.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Peptide affinity purified.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: ACCN2 polyclonal antibody detects endogenous levels of ACCN2 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 60 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of ACCN2 on SH-SY-5Y cell lysate using anti-ACCN2 antibody at 1\/2,000 dilution., Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-ACCN2 antibody. Counter stained with hematoxylin.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: ASIC1, BNaC2, ASIC1, ACCN2, BNAC2, ACCN2, ACCN2, Acid sensing ion channel 1, Acid sensing ion channel 1a protein, Acid sensing ion channel, Acid-sensing ion channel 1, AI843610, Amiloride sensitive cation channel 2 neuronal, Amiloride-sensitive cation channel 2, ASIC, ASIC1, ASIC1A, B530003N02Rik, BNaC2, Brain sodium channel 2, Cation channel amiloride sensitive neuronal 2, hBNaC2, neuronal,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Synthetic peptide within human ACCN2 aa 460-500.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42979757064371,"sku":"BS90019-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42979757097139,"sku":"BS90019-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_b4aba68d-0910-4297-b674-aa3366474648.jpg?v=1705748668","url":"https:\/\/afsbio.com\/products\/accn2-polyclonal-antibody-bs90019","provider":"AFSBio Inc.","version":"1.0","type":"link"}