{"product_id":"ace2-rabbit-polyclonal-antibody-es7007","title":"ACE2 Rabbit Polyclonal Antibody - ES7007","description":"\u003cp\u003eACE2 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES7007-50, ES7007-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: angiotensin I converting enzyme 2(ACE2) Homo sapiens The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ACE2, Angiotensin-converting enzyme 2, ACE-related carboxypeptidase, Angiotensin-converting enzyme homolog, ACEH, Metalloprotease MPROT15\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human ACE2. AA range:416-465\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: ACE2\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: ACE2 Polyclonal Antibody detects endogenous levels of ACE2 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells (at protein level) (PubMed:15141377), Expressed in enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level) (PubMed:15141377), Expressed in the renal proximal tubule and the small intestine (at protein level) (PubMed:18424768), Expressed in heart, kidney, testis, and gastrointestinal system (at protein level) (PubMed:10969042, PubMed:10924499, PubMed:15231706, PubMed:12459472, PubMed:15671045, PubMed:32715618, PubMed:32170560), In lung, expressed at low levels in some alveolar type 2 cells, the expression seems to be individual-specific (at protein level) (PubMed:32425701, PubMed:15141377, PubMed:32715618, PubMed:32170560, PubMed:33432184), Expressed in nasal epith\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 90kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Renin-angiotensin system, Protein digestion and absorption, Coronavirus disease - COVID-19\u003c\/p\u003e\n\n\u003cp\u003eFunction: Cofactor: Binds 1 chloride ion per subunit\u003cbr\u003e\nCofactor: Binds 1 zinc ion per subunit\u003cbr\u003e\nEnzyme Regulation: Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat\u003cbr\u003e\nFunction: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses\u003cbr\u003e\nInduction: Up-regulated in failing heart\u003cbr\u003e\nPTM: N-glycosylation on Asn-90 may limit SARS infectivity\u003cbr\u003e\nSimilarity: Belongs to the peptidase M2 family\u003cbr\u003e\nSubunit: Interacts with ITGB1. Interacts with SARS-CoV and HCoV-NL63\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: [Processed angiotensin-converting enzyme 2]: Secreted, Cell membrane, Single-pass type I membrane protein Cytoplasm Cell projection, cilium Apical cell membrane Detected in both cell membrane and cytoplasm in neurons, [Isoform 2]: Apical cell membrane\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: ACE2\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Angiotensin-converting enzyme 2\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 70008\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q8R0I0\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313672769715,"sku":"ES7007-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313672802483,"sku":"ES7007-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/ace2-rabbit-polyclonal-antibody-es7007","provider":"AFSBio Inc.","version":"1.0","type":"link"}