{"product_id":"acetyl-coa-carboxylase-rabbit-pab-a23986","title":"Acetyl-CoA Carboxylase Rabbit pAb - A23986","description":"\u003cp\u003eAcetyl-CoA Carboxylase Rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A23986-20, A23986-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation\/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Polyclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 265kDa\/276kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: 280kDa\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide .\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 31\/32\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q13085\/O00763\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ACC; ACAC; ACC1; ACCA; Acac1; hACC1; ACACAD; ACCalpha; ACACalpha; Acetyl-CoA Carboxylase\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis),  pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: WB, 1:1000 - 1:5000 ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cardiovascular; Lipids \/ Lipoproteins、Fatty Acids Synthesis; Signal Transduction；Metabolism；Mitochondrial；Cancer Metabolism.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: ACACA\/ACACB\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189847842995,"sku":"A23986-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189847875763,"sku":"A23986-100","price":417.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_ca3d680c-a3a9-43b2-87b3-25430a63fb63.png?v=1766436686","url":"https:\/\/afsbio.com\/products\/acetyl-coa-carboxylase-rabbit-pab-a23986","provider":"AFSBio Inc.","version":"1.0","type":"link"}