{"product_id":"acetyl-dnmt1-k1127-k1129-k1131-k1133-rabbit-pab-a5595","title":"Acetyl-DNMT1-K1127\/K1129\/K1131\/K1133 Rabbit pAb - A5595","description":"\u003cp\u003eAcetyl-DNMT1-K1127\/K1129\/K1131\/K1133 Rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A5595-20, A5595-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Acetylated Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-P, IF\/ICC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 183kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: Refer to figures\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide .\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 1786\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P26358\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; m.HsaI; Acetyl-DNMT1-K1127\/K1129\/K1131\/K1133\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS with 0.09% Sodium azide, 50% glycerol, pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: IHC-P, 1:50 - 1:100 IF\/ICC, 1:50 - 1:100 ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics Nuclear Signaling, Epigenetic writers and erasers of core Histones, Protein phosphorylation.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: DNMT1\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189950144691,"sku":"A5595-20","price":179.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189950177459,"sku":"A5595-100","price":515.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_9b11ecf1-3378-469f-ae1f-b87350cf8e35.png?v=1766438689","url":"https:\/\/afsbio.com\/products\/acetyl-dnmt1-k1127-k1129-k1131-k1133-rabbit-pab-a5595","provider":"AFSBio Inc.","version":"1.0","type":"link"}