{"product_id":"acha4-polyclonal-antibody-bt-ap14072","title":"ACHA4 Polyclonal Antibody - BT-AP14072","description":"\u003cp\u003eACHA4 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP14072-20, BT-AP14072-50, BT-AP14072-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a nicotinic acetylcholine receptor| which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine| which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cancer; Metabolism; Neuroscience\u003c\/p\u003e \n\n\u003cp\u003eTarget Protein: CHRNA4\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Neuronal acetylcholine receptor subunit alpha-4\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P43681; Mouse: O70174; Rat: P09483\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Neuronal acetylcholine receptor subunit alpha-4\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 1137\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239039197363,"sku":"BT-AP14072-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239039230131,"sku":"BT-AP14072-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239039262899,"sku":"BT-AP14072-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_952852ba-f391-4b70-ae20-4d87e52e2a7b.png?v=1769388276","url":"https:\/\/afsbio.com\/products\/acha4-polyclonal-antibody-bt-ap14072","provider":"AFSBio Inc.","version":"1.0","type":"link"}