{"product_id":"acinus-phospho-s1180-polyclonal-antibody-bs64570","title":"Acinus (Phospho-S1180) Polyclonal Antibody-BS64570","description":"\u003cp\u003eAcinus (Phospho-S1180) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS64570-50, BS64570-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q9UKV3\/O95104\/Q8TF01\/Q14498\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: Acinus (apoptotic chromatin condensation inducer in the nucleus) is a caspase substrate that has been implicated in nuclear changes during apoptosis. Chromatin condensation and DNA fragmentation are both nuclear morphological features associated with apoptosis. Acinus is expressed in different isoforms (L, S, S') most likely generated by alternative splicing. During apoptosis Acinus is cleaved by caspase-3 to generate a 23 kDa fragment that was reported to induce chromatin condensation. Acinus has been identified to be a component of the spliceosome complex, ASAP, suggesting a role in pre-mRNA processing. Down regulation of Acinus by RNA interference inhibits cell growth (5). This study also found that loss of Acinus inhibits DNA fragmentation but not chromatin condensation during apoptosis.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Acinus (Phospho-S1180) polyclonal antibody detects endogenous levels of Acinus protein only when phosphorylated at Ser1180.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 210 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western Blot (WB) analysis of Acinus (Phospho-S1180) polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLane A: A549 whole cell lysate\u003cbr\u003e\nLane B: Hela whole cell lysate\u003cbr\u003e\nLane C: Jurkat whole cell lysate\u003cbr\u003e\nLane D: NIH3T3 whole cell lysate\u003cbr\u003e\nLane E: H9C2 whole cell lysate\u003cbr\u003e\nLane F: PC12 whole cell lysate\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Apoptotic chromatin condensation inducer in the nucleus; Acinus; ACIN1; ACINUS; KIAA0670; SR-related and CTD-associated factor 4; CTD-binding SR-like protein RA4; Splicing factor, arginine\/serine-rich 15; SCAF4; KIAA1172; SFRS15; Arginine\/serine-rich protein PNISR; PNN-interacting serine\/arginine-rich protein; SR-related protein; SR-rich protein; Serine\/arginine-rich-splicing regulatory protein 130; \u003cbr\u003e\nSRrp130; Splicing factor, arginine\/serine-rich 130; Splicing factor, arginine\/serine-rich 18; PNISR; C6orf111; SFRS18; SRRP130; HSPC261; HSPC306; RNA-binding protein 39; CAPER alpha; CAPERalpha; Hepatocellular carcinoma protein 1; RNA-binding motif protein 39; RNA-binding region-containing protein 2; Splicing factor HCC1; RBM39; HCC1; RNPC2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic phosphopeptide derived from human Acinus around the phosphorylation site of Serine 1180.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylation\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42923463540915,"sku":"BS64570-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42923463573683,"sku":"BS64570-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_6089d036-495a-4197-996f-ab8709a5a33f.jpg?v=1703849975","url":"https:\/\/afsbio.com\/products\/acinus-phospho-s1180-polyclonal-antibody-bs64570","provider":"AFSBio Inc.","version":"1.0","type":"link"}