{"product_id":"ack-polyclonal-antibody-bt-ap00179","title":"ACK Polyclonal Antibody - BT-AP00179","description":"\u003cp\u003eACK Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP00179-20, BT-AP00179-50, BT-AP00179-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: TNK2 encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The tyrosine kinase non receptor 2 may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc43Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Cancer\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: TNK2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: ACK Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 114327\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q07912; Mouse: O54967\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: TNK2; ACK1; Activated CDC42 kinase 1; ACK-1; Tyrosine kinase non-receptor protein 2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 10188; Mouse: 51789\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240089084083,"sku":"BT-AP00179-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240089116851,"sku":"BT-AP00179-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240089149619,"sku":"BT-AP00179-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_98933886-9b6e-46ee-9608-5354103785a2.png?v=1769403276","url":"https:\/\/afsbio.com\/products\/ack-polyclonal-antibody-bt-ap00179","provider":"AFSBio Inc.","version":"1.0","type":"link"}