{"product_id":"actinin-α1-2-3-4-w48-polyclonal-antibody-bs2206","title":"Actinin-α1\/2\/3\/4 (W48) Polyclonal Antibody-BS2206","description":"\u003cp\u003eActinin-α1\/2\/3\/4 (W48) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS2206-50, BS2206-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P12814\/P35609\/Q08043\/O43707\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e \n\n\u003cp\u003eBackground: The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and α-actinins. There are four tissue-specific α-actinins, namely α-actinin-1, α-actinin-2, α-actinin-3 and α-actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each α-actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding α-actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Actinin-α1\/2\/3\/4 (W48) polyclonal antibody detects endogenous levels of total α-actinin protein.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of Actinin-α1\/2\/3\/4 (W48) pAb at 1:500 dilution\u003cbr\u003e\nLane 1: The Kidney tissue lysate of Mouse (40ug)\u003cbr\u003e\nLane 2: The Brain tissue lysate of Rat (40ug)\u003cbr\u003e\nLane 3: HEK293T whole cell lysate (40ug)\u003cbr\u003e\nLane 4: PC3 whole cell lysate (40ug)\u003cbr\u003e\nLane 5: U-87MG whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of Actinin-α1\/2\/3\/4 (W48) pAb in paraffin-embedded human liver carcinoma tissue at 1:50.showing cytoplasmic and nucleus staining. Negative control (the right) Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.\u003c\/p\u003e \n\n\u003cp\u003eBioworld Molecular Weight: ~ 103 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: pan-α-Actinin; α-Actinin-pan; Actinin-α; Actinin α; α Actinin; α-Actinin; Alpha-actinin-4; F-actin cross-linking protein; Non-muscle alpha-actinin 4; ACTN4; α-Actinin4; Actinin α4; Actininα4; αActinin-4; Actinin-α4; α-actinin-4; Alpha-actinin-1; Alpha-actinin cytoskeletal isoform; Non-muscle alpha-actinin-1; ACTN1; α-Actinin1; Actinin α1; Actininα1; αActinin-1; Actinin-α1; α-actinin-1; Alpha-actinin-2; Alpha-actinin skeletal muscle isoform 2; ACTN2; α-Actinin2; Actinin α2; Actininα2; αActinin-2; Alpha-actinin-3; Alpha-actinin skeletal muscle isoform 3; ACTN3; α-Actinin3; Actinin α3; Actininα3; αActinin-3; Actinin-α3; α-actinin-2; α-actinin-3\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 30-60 of Human Actinin-α1.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42953221308595,"sku":"BS2206-50","price":254.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42953221341363,"sku":"BS2206-100","price":442.75,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_11c2bbfd-74a1-44ba-be16-86b4fe8b126a.jpg?v=1705057044","url":"https:\/\/afsbio.com\/products\/actinin-%ce%b11-2-3-4-w48-polyclonal-antibody-bs2206","provider":"AFSBio Inc.","version":"1.0","type":"link"}