{"product_id":"actinin-α1-polyclonal-antibody-ra21635","title":"Actinin-α1 Polyclonal Antibody - RA21635","description":"\u003cp\u003eActinin-α1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA21635-50, RA21635-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: actinin alpha 1 (ACTN1) Homo sapiens Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eCondition: PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: WB: 1:1000-2000 IHC: 1:200-500\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: ACTN1; Alpha-actinin-1; Alpha-actinin cytoskeletal isoform; F-actin cross-linking protein; Non-muscle alpha-actinin-1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC-p; IF (paraffin section)\u003c\/p\u003e \n\n\u003cp\u003eSpecies Cross-Reactivity: Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 87\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 103\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P12814\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121074954419,"sku":"RA21635-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121074987187,"sku":"RA21635-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_2b238e06-203f-4043-af3c-581e445a8a45.png?v=1773370528","url":"https:\/\/afsbio.com\/products\/actinin-%ce%b11-polyclonal-antibody-ra21635","provider":"AFSBio Inc.","version":"1.0","type":"link"}