{"product_id":"actinin-alpha1-2-3-4-polyclonal-antibody-bt-ap00216","title":"Actinin-Alpha1\/2\/3\/4 Polyclonal Antibody - BT-AP00216","description":"\u003cp\u003eActinin-Alpha1\/2\/3\/4 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP00216-20, BT-AP00216-50, BT-AP00216-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. ACTN1 encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for ACTN1.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Others\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ACTN1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Actinin-alpha1\/2\/3\/4 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 104854\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P12814\/P35609\/Q08043\/O43707; Rat: Q9Z1P2\/Q9QXQ0\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: ACTN1; Alpha-actinin-1; Alpha-actinin cytoskeletal isoform; F-actin cross-linking protein; Non-muscle alpha-actinin-1; ACTN2; Alpha-actinin-2; Alpha-actinin skeletal muscle isoform 2; F-actin cross-li\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 87\/88\/89\/81; Mouse: 109711\/11472\/11474\/60595; Rat: 81634\/63836\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240091115699,"sku":"BT-AP00216-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240091148467,"sku":"BT-AP00216-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240091181235,"sku":"BT-AP00216-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_db9b4726-f51c-411f-a5ee-1081dc764e75.png?v=1769403304","url":"https:\/\/afsbio.com\/products\/actinin-alpha1-2-3-4-polyclonal-antibody-bt-ap00216","provider":"AFSBio Inc.","version":"1.0","type":"link"}