{"product_id":"actinin-alpha2-monoclonal-antibody-bt-mca0137","title":"Actinin- Alpha2 Monoclonal Antibody - BT-MCA0137","description":"\u003cp\u003eActinin- Alpha2 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA0137-50, BT-MCA0137-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer; Signal transduction; Metabolism\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ACTN2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IF, ICC\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human,Rat,Bovine,Chicken,Dog,Pig,Zebrafish\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Alpha-actinin-2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P35609; Mouse: Q9JI91\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: ACTN2; Alpha-actinin-2; Alpha-actinin skeletal muscle isoform 2; F-actin cross-linking protein\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 88\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238658302131,"sku":"BT-MCA0137-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238658334899,"sku":"BT-MCA0137-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_3d53e021-cfca-4b7d-ac20-2892a628696b.png?v=1769383499","url":"https:\/\/afsbio.com\/products\/actinin-alpha2-monoclonal-antibody-bt-mca0137","provider":"AFSBio Inc.","version":"1.0","type":"link"}