{"product_id":"active-casp3-monoclonal-antibody-e-ab-22115","title":"Active CASP3 Monoclonal Antibody - E-AB-22115","description":"\u003cp\u003eActive CASP3 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-22115-60, E-AB-22115-120, E-AB-22115-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Active Caspase-3\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: A830040C14Rik; Apopain; CASP-3; CASP3; CASP3; Casp3a; Caspase 3; Caspase 3; apoptosis-related cysteine peptidase; Caspase 3; apoptosis-related cysteine protease; Caspase 3; apoptosis-related cysteine protease a; Caspase-3 subunit p12; CC3; CPP-32; CPP32; CPP32B; Cysteine protease CPP32; EC 3.4.22.56; LICE; mldy; OTTHUMP00000165052; OTTHUMP00000165053; OTTHUMP00000165054; PARP cleavage protease; Procaspase3; Protein Yama; SCA 1; SCA-1; SREBP cleavage activity 1; Yama\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cell Biology, Metabolism, Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC-p, IF\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone No.: Clone:5A2\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P42574\u003c\/p\u003e\n\n\u003cp\u003eBackground: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant Protein\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Protein A purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:1000, IHC 1:100-1:200, IF 1:100-1:200\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 17kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43148617842867,"sku":"E-AB-22115-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43148617875635,"sku":"E-AB-22115-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43148617908403,"sku":"E-AB-22115-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_7e5617c6-723d-400c-add8-5c4cfb43d945.png?v=1710326815","url":"https:\/\/afsbio.com\/products\/active-casp3-monoclonal-antibody-e-ab-22115","provider":"AFSBio Inc.","version":"1.0","type":"link"}