{"product_id":"active-caspase-3-monoclonal-antibody-5e1-bt-mca0002","title":"Active Caspase-3 Monoclonal Antibody (5E1) - BT-MCA0002","description":"\u003cp\u003eActive Caspase-3 Monoclonal Antibody (5E1)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-MCA0002-20, BT-MCA0002-50, BT-MCA0002-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology; Metabolism; Cancer\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CASP3\u003c\/p\u003e\n\n\u003cp\u003eApplications: IF, ICC, WB, IHC-p\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human,Mouse,Rat,Chicken\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Caspase-3\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P42574; Mouse: P70677; Rat: P55213\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 836\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240024826035,"sku":"BT-MCA0002-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240024858803,"sku":"BT-MCA0002-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240024891571,"sku":"BT-MCA0002-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_c573b6c9-415c-48e0-b4bc-eb72b14cb044.png?v=1769402307","url":"https:\/\/afsbio.com\/products\/active-caspase-3-monoclonal-antibody-5e1-bt-mca0002","provider":"AFSBio Inc.","version":"1.0","type":"link"}