{"product_id":"actn1-polyclonal-antibody-e-ab-60220","title":"ACTN1 Polyclonal Antibody - E-AB-60220","description":"\u003cp\u003eACTN1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-60220-60, E-AB-60220-120, E-AB-60220-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: ACTN1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: ACTN1; BDPLT15\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Developmental Biology, Signal Transduction, Stem Cells\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P12814\u003c\/p\u003e\n\n\u003cp\u003eBackground: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human ACTN1 (NP_001123477.1).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB \t1:500-1:2000   IHC \t1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 102kDa\/103kDa\/105kDa\/107kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 105kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146044211379,"sku":"E-AB-60220-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146044244147,"sku":"E-AB-60220-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146044276915,"sku":"E-AB-60220-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_f4f69fe6-9ae4-4ff0-9207-2a05384c58c8.png?v=1710290492","url":"https:\/\/afsbio.com\/products\/actn1-polyclonal-antibody-e-ab-60220","provider":"AFSBio Inc.","version":"1.0","type":"link"}