{"product_id":"actn1-polyclonal-antibody-e-ab-70225","title":"ACTN1 Polyclonal Antibody - E-AB-70225","description":"\u003cp\u003eACTN1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-70225-60, E-AB-70225-120, E-AB-70225-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: ACTN1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: actinin 1 smooth muscle; Actinin alpha 1; actinin; alpha 1; ACTN 1; Actn1; ACTN1; Alpha Actinin 1; Alpha actinin cytoskeletal isoform; Alpha-actinin cytoskeletal isoform; Alpha-actinin-1; BDPLT15; F actin cross linking protein; F-actin cross-linking protein; FLJ40884; FLJ54432; Non muscle alpha actinin 1; Non-muscle alpha-actinin-1\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Developmental Biology, Signal Transduction, Stem Cells\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P12814,Q7TPR4,Q9Z1P2\u003c\/p\u003e\n\n\u003cp\u003eBackground: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.66 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein corresponding to Mouseα-actinin1\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:1000-1:3000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 102-107kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 110kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146513645747,"sku":"E-AB-70225-60","price":224.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146513678515,"sku":"E-AB-70225-120","price":364.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146513711283,"sku":"E-AB-70225-200","price":574.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_272b8101-e31f-4303-afa9-f57fd71dad84.png?v=1710296680","url":"https:\/\/afsbio.com\/products\/actn1-polyclonal-antibody-e-ab-70225","provider":"AFSBio Inc.","version":"1.0","type":"link"}